5 Sleep medicine practitioners and others can now optimize selection of bupropion formulations to minimize the risk of insomnia. 5 While bupropion is not a classic stimulant, 6 its ability to increase dopamine and norepinephrine can result in nonspecific stimulation. Bupropion is a weak norepinephrine-dopamine reuptake inhibitor that does not show significant antagonism at histaminic or muscarinic receptors and has a low prevalence of sexual side effects. 4 Awareness of the kinetics and pharmacology of bupropion can mitigate such sleep-disturbing effects while exploiting antidepressant effects. 1 While bupropion’s advantages include a relatively low risk of inducing restless leg syndrome 2 or rapid eye movement sleep behavioral disorder, 3 its alerting effects may disrupt sleep, particularly when a short-acting formulation is administered late in the day. * Corresponding author: Kamal Gandotra, MD, Louis Stokes VAMC, 10701 East Blvd, Cleveland, OH 44106 ( is a widely prescribed antidepressant with efficacy for major depressive disorder, seasonal affective disorder, smoking tobacco cessation, and attention-deficit/hyperactivity disorder. JDivision of Pulmonary, Critical Care and Sleep Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio IGeriatric Research Educational and Clinical Center (GRECC), Louis Stokes VA Medical Center, Cleveland, Ohio HDepartments of Psychiatry and Psychology, Case Western Reserve University, Cleveland, Ohio GNational PBM Clinical Pharmacy Program Manager VHA Pharmacy Benefits Management Services, Hines, Illinois 2021 23(1):20br02621.ĪLouis Stokes VA Medical Center, Cleveland, OhioīPsychiatry Service, Louis Stokes VA Medical Center, Cleveland, OhioĬDepartment of Psychiatry, Case Western Reserve University, Cleveland, OhioĭDivision of Pulmonary, Critical Care, and Sleep Medicine, Louis Stokes VA Medical Center, Cleveland, OhioĮSleep Disorders Center, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MarylandįDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda Development of insomnia associated with different formulations of bupropion. To cite: Gandotra K, Jaskiw GE, Williams SG, et al.
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